One of the biggest challenges for a site that are heavily dependent on database, where to cache all that data.
To solve this issue, we have multiple products offerings in the market- Gigaspaces, Infinispan in the open source world. Vendors like IBM and Oracle have re-branded or released products like WebSphere extreme scale , Oracle In-Memory database.
For the discerning customers that are mostly IBM shops, the WebSphere extreme scale is a nice product that works very well with the existing WebSphere Stack of Applications. There are some good resources available on the same
IBM Redbooks: User's guide to WebSphere eXtreme Scale
Another upcoming good book is the IBM WebSphere eXtreme Scale 6 by Anthony Chaves which promises to demystify the data grid concepts and their usage in the applications. I will post my review on the book pretty soon.